ascopubs.org

A first-in-human phase I single-agent dose-escalation, food effect and dose expansion study of oral ONC206 in recurrent and rare primary central nervous system neoplasms.

A phase II/III randomized, blinded study of tozuleristide for fluorescence imaging detection during neurosurgical resection of pediatric primary central nervous system (CNS) tumors: PNOC012 (Pacific ...
News Medical

DRD2 expression plays crucial role in protecting mice against kidney injury, hypertension

Dopamine signaling in the kidneys plays a critical role in blood pressure regulation and is responsible for nearly half of the salt and water excretion that occurs in response to increased dietary ...
GEN

Dopamine Receptor–Drug Structure Could Aid Development of Safer Antipsychotics

Scientists at the University of North Carolina (UNC) at Chapel Hill have resolved the structure of the D 2 dopamine receptor (DRD2) bound to the antipsychotic drug risperidone. The researchers, led by ...
ascopubs.org

Anticancer and immunostimulatory activity of the imipridone ONC201, a selective DRD2 antagonist, in advanced cancer patients.

A phase I dose expansion cohort study of dasatinib in combination with bevacizumab in advanced solid tumors (NCT01445509). This is an ASCO Meeting Abstract from the 2017 ASCO Annual Meeting I. This ...
Nature

Association between DRD2 and DRD3 gene polymorphisms and gastrointestinal symptoms induced by levodopa therapy in Parkinson’s disease

A total of 217 Brazilian PD patients were recruited and evaluated at the Movement Disorder Clinics at Hospital de Clínicas de Porto Alegre, Brazil, from 2006 to 2014. This sample has been fully ...
C&EN

Structure of antipsychotic drug target solved

Two years ago at a scientific meeting, Bryan L. Roth of the University of North Carolina, Chapel Hill, announced that he and his colleagues were trying to solve the structure of the D 2 dopamine ...