Clathrin-mediated endocytosis (CME) is an essential cellular process that mediates the internalisation of diverse plasma membrane components and extracellular cargo. This mechanism relies on the ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells. Conventionally, proteins that are ...

Drug discovery is shifting from static snapshots to moving pictures. Instead of inferring how medicines work from end results ...

Their findings, published in a Cell Reports paper titled “Palmitoylation and PDE6δ regulate membrane-compartment-specific substrate ubiquitylation and degradation,” have implications for developing ...

For Amy Engevik, an epithelial cell biologist at the Medical University of South Carolina who studies cell function in the gastrointestinal tract, protein location matters more than abundance. She ...

This illustration shows how the membrane trafficking protein VAMP72 gradually changed during plant evolution to give rise to VAMP727, which functions in transporting storage proteins to vacuoles. The ...

Amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease, has long mystified scientists with its intricate cellular mechanisms. However, a recent groundbreaking study conducted by ...

Real-time and in-line accurate measuring of protein (monoclonal antibody, or mAb) concentration has been shown across a wide dynamic range (0–135 g/L) through the ...