Cell division is a process of remarkable precision: during each cycle, the genetic material must be evenly distributed between the two daughter cells. To achieve this, duplicated chromosomes, known as ...

Cohesin is a large ring-shaped protein complex that mediates cohesion between sister chromatids. New experiments show that the sister chromatids of a minichromosome are entrapped by monomeric cohesin ...

Since sister chromatids are identical to each other, recombination with a sister chromatid is expected, in most cases, to be a precise way for repairing DNA damage. Recombination between 2 different ...

The cohesin complex comprises a heterodimer of Smc1 and Smc3 bridged by the Scc1 kleisin subunit. These three subunits are thought to form a tripartite complex that holds newly replicated sister ...

Meiotic recombination initiates via programmed double-strand breaks (DSBs). We investigate whether, at a given initiation site, DSBs occur independently among the four available chromatids. For a ...

Each replicated chromosome is made up of two identical strands called chromatids that are joined together. Each chromatid is a full length DNA molecule. The stages outlined in the following example ...