Corticospinal motor neurons are the motor system’s foreman, according to Hande Özdinler of the Northwestern University Feinberg School of Medicine in Chicago. They listen to what the brain wants, and ...

Scientists have revealed a mechanism underlying the cellular degeneration of the upper motor neurons that die in ALS, and developed a model system that will allow further research on the degeneration.

Cognitive impairment is a common feature of ALS: frontotemporal dementia and ALS constitute the ends of a spectrum reflecting different manifestations of the same pathogenic mechanism Upper and lower ...

Amyotrophic lateral sclerosis, already a rare condition affecting one to three people in 100,000, nonetheless garners most of the attention in the field of motor neuron disease. Those conditions that ...

Scientists have demonstrated for the first time that it is possible to specifically modify gene expression in diseased upper motor neurons, brain cells that break down in ALS. The study provides ...

The brain is indeed a target for treating ALS (amyotrophic lateral sclerosis), Northwestern Medicine scientists have discovered. This flips a long-standing belief that the disease starts in the spinal ...

The classification of ALS can vary depending on the criteria used. The traditional definitions of ALS subgroups are based on the extent of involvement of upper and lower motor neurons, although other ...

Current clinical assessments evaluating selective voluntary motor control are measured on an ordinal scale. We combined the Selective Control of the Upper Extremity Scale (SCUES) with surface ...

Scientists from Northwestern Medicine and the University of Belgrade have pinpointed the electrophysiological mechanism behind upper motor neuron (UMN) disease, unlocking the door to potential ...

Motor neuron disease (MND) is a progressive condition that occurs when certain nerve cells degenerate and die. There are two types of motor neuron cells. The upper motor neuron begins in the brain and ...

Hyperrelexic, overactive or spastic bladder or bowels occur with spinal cord injury at or above T12. The primary characteristic of this type of injury is increased organ spasms. The UMN bladder may ...