Primary lateral sclerosis (PLS) and amyotrophic lateral sclerosis (ALS) are neurodegenerative diseases. PLS typically develops slowly, while ALS rapidly affects mobility and can become fatal.

Primary lateral sclerosis (PLS) is a rare neurological disorder that affects the motor neurons in the brain and spinal cord, which control movement. It is a form of motor neuron disease (MND). PLS ...

A diagnosis of amyotrophic lateral sclerosis can be overlooked by clinicians unfamiliar with the various signs of the disease. ALS is purely a motor neuron disease; sensory neurons are not affected. 4 ...

Primary lateral sclerosis (PLS) is a motor neuron disease variation of ALS (amyotrophic lateral sclerosis) but far more rare. PLS refers to patients who seem to have disruptions with only upper motor ...

Hereditary spastic paraplegia (HSP), also known as familial spastic paraparesis, is a term used for a group of inherited diseases that affect the upper motor neurons traveling from the brain through ...

Amyotrophic lateral sclerosis (ALS) is a devastating, fatal neuromuscular disease. Most patients die within 2 to 5 years of diagnosis. The disease stems from death of upper and lower motor neurons ...

Scientists have uncovered how a newly discovered gene, NEK1, in which mutations have been linked to ALS cases, disrupts the function of the motor neuron and causes it to degenerate and die. The viral ...

Dr. Amanda C. Guidon: A 60-year-old man was evaluated in the neurology clinic of this hospital because of weakness and difficulty chewing. Six months before this presentation, weakness developed in ...

Progressive muscular atrophy (PMA) is a rare adult-onset motor neuron disease. Although there’s no cure, treatments may slow down nerve damage and reduce symptoms. Progressive muscular atrophy (PMA) ...

BUFFALO, N.Y. — Inside neurons, motor proteins haul precious cargo, moving essential goods along thread-like roadways called microtubule tracks. This miniature highway system is vital for keeping ...