BMJ

Smoking is a major preventable risk factor for rheumatoid arthritis: estimations of risks after various exposures to cigarette smoke

2 Department of Medicine, Rheumatology Unit, Karolinska Institutet/Karolinska Hospital, Stockholm, Sweden 3 Unit of Clinical Immunology, Uppsala University/Akademiska Sjukhuset, Uppsala, Sweden 4 ...
BMJ

Extra-articular disease manifestations in rheumatoid arthritis: incidence trends and risk factors over 46 years

2 Department of Health Sciences Research, Mayo Clinic and Mayo Graduate School of Medicine, Rochester, Minnesota, USA 3 Division of Rheumatology, Mayo Clinic and Mayo Graduate School of Medicine, ...
BMJ

The regulation of human MMP-13 by licofelone, an inhibitor of cyclo-oxygenases and 5-lipoxygenase, in human osteoarthritic chondrocytes is mediated by the inhibition of the p38 ...

Background: MMP-13 is one of the most important metalloproteases (MMP) involved in osteoarthritis. Licofelone, a novel dual inhibitor of cyclo-oxygenases (COX) and 5-lipoxygenase (5-LOX), can modulate ...
BMJ

Etanercept in patients with inflammatory hand osteoarthritis (EHOA): a multicentre, randomised, double-blind, placebo-controlled trial

Correspondence to Professor Margreet Kloppenburg, Department of Rheumatology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands; g.kloppenburg{at}lumc.nl Objective Hand osteoarthritis ...
BMJ

2022 American College of Rheumatology/European Alliance of Associations for Rheumatology classification criteria for granulomatosis with polyangiitis

Objective To develop and validate revised classification criteria for granulomatosis with polyangiitis (GPA). Methods Patients with vasculitis or comparator diseases were recruited into an ...
BMJ

The number of flares patients experience impacts on damage accrual in systemic lupus erythematosus: data from a multiethnic Latin American cohort

Correspondence to Bernardo A Pons-Estel, Hospital Provincial de Rosario, Rosario, Argentina, Avenida del Huerto 1375, Rosario, 2000, Argentina; baponsestel{at}buenaventuraguarani.com.ar Purpose To ...
BMJ

Psoriasis assessment tools in clinical trials

1 Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA 2 Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, UT, USA ...
BMJ

Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients

Objectives To assess the prevalence of the main causes of morbi-mortality in the antiphospholipid syndrome (APS) during a 10-year-follow-up period and to compare the frequency of early manifestations ...
BMJ

2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome

Objectives To develop and validate an international set of classification criteria for primary Sjögren's syndrome (SS) using guidelines from the American College of Rheumatology (ACR) and the European ...
BMJ

Elevated liver enzyme tests among patients with rheumatoid arthritis or psoriatic arthritis treated with methotrexate and/or leflunomide

Introduction: Potential hepatotoxicity associated with disease-modifying antirheumatic drugs (DMARDs) requires laboratory monitoring. In patients with rheumatoid arthritis (RA) or psoriatic arthritis ...
BMJ

Survival in adults and children with systemic lupus erythematosus: a systematic review and Bayesian meta-analysis of studies from 1950 to 2016

Objective To determine trends in survival among adult and paediatric patients with systemic lupus erythematosus (SLE) from 1950 to the present. Methods We performed a systematic literature review to ...
BMJ

How to diagnose axial spondyloarthritis early

Background: Chronic low back pain (LBP), the leading symptom of ankylosing spondylitis (AS) and undifferentiated axial spondyloarthritis (SpA), precedes the development of radiographic sacroiliitis, ...