Our DNA is compacted and arranged into chromosomes, most of which are shaped like X’s. The ends of the chromosomes' arms are protected with caps known as telomeres. Telomeres are made up of highly ...

DNA replication is a fundamental process for all known life forms, and it’s essential for biological inheritance. This intricate process ensures that genetic information is accurately passed on from ...

Hematology experts offer evaluation and monitoring for anemia, marrow failure, and blood cancers. They can also determine if a bone marrow transplants is right for you. Pulmonary specialists offer ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Chromosome ends require protection from the ...

A groundbreaking study has revealed that your mom and dad’s DNA don’t just pass on telomere length, they actively reshape it in the first days of life, influencing how we age and our risk of ...

MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...

Transposons are critical drivers of bacterial evolution that have been studied for many decades and have been the subject of Nobel Prize winning research. Now, researchers from Cornell University have ...

Early findings showed EXG-34217 elongated telomere length ex vivo. The Food and Drug Administration (FDA) has granted Orphan Drug designation to EXG-34217 for the treatment of telomere biology ...

BALTIMORE, Feb. 20, 2025 (GLOBE NEWSWIRE) -- Elixirgen Therapeutics, Inc., a clinical-stage biotechnology company focused on treating rare diseases, today announced that the U.S. Food and Drug ...

A new method exposes key details of the mechanism behind calcium signaling in prokaryotes for the first time. Working in a Listeria monocytogenes model, researchers from Umeå University (Sweden) led ...

The length of telomeres that protect the ends of our chromosomes should be tightly regulated. Those that are too long predispose to cancer, and those that are too short lose their protective ability, ...

In absence of TARG1, ADP-ribose accumulated at telomeres, leading to disruption of telomere replication and premature telomere shortening. To show that these telomere defects were due to modification ...