The new molecules selectively reduced inflammatory signaling in human immune cells without affecting other immune pathways.

A new study led by researchers at the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer ...

Navigating the world is no mean feat, especially when the world pushes back. For instance, airflow hitting a fly on its right ...

A familiar Korean side dish is gaining scientific traction for its ability to subtly fine-tune the body’s immune system.

Specifically, a molecule released by immune cells during the inflammatory response, called interferon-gamma (IFNγ), triggers long-term change in how neurons regulate their genes that, without killing ...

New immune profiling data confirms disease-modifying mechanism, reinforces earlier signals of fibrosis resolution, lung ...

Background Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for ...

Gene-set analysis seeks to identify the biological mechanisms underlying groups of genes with shared functions. Large language models (LLMs) have shown promise in generating functional descriptions ...

In modern functional genomics, understanding how specific genes control cellular behavior requires both targeted intervention and high-resolution analysis. That’s where Perturb-Seq comes in—a method ...

Researchers have developed a gene therapy that significantly slowed motor function loss in preclinical models of amyotrophic lateral sclerosis (ALS), offering new hope for treating the devastating ...

Researchers at University of California San Diego School of Medicine have developed a gene therapy for Alzheimer’s disease that could help protect the brain from damage and preserve cognitive function ...

This scan of a mouse brain shows blood vessels (red), brain cells (green), and amyloid plaques (blue). A new gene therapy treatment developed by UC San Diego works by reprogramming the behavior of ...