What is Alpha-1 antitrypsin deficiency? Alpha-1 antitrypsin deficiency (sometimes just called “Alpha-1”) is an inherited genetic disorder that causes low levels of a protein (AAT) that …

Dec 6, 2025 · Learn about the symptoms and risk factors of alpha-1-antitrypsin deficiency, a condition passed down in families, that can affect the lungs, liver or both.

Nov 25, 2025 · Learn about the causes, symptoms, and treatment for alpha-1 antitrypsin (AAT) deficiency, along with questions for your doctor and tips for living with it.

Alpha-1 antitrypsin deficiency occurs worldwide, but its prevalence varies by population. This disorder affects about 1 in 1,500 to 3,500 individuals with European ancestry. It is uncommon …

Alpha-1 antitrypsin is the main protein of the alpha-globulin 1 region. Another name used is alpha-1 proteinase inhibitor (α 1 -PI). The gene is located on the long arm of chromosome 14 …

Alpha-1 antitrypsin deficiency (AATD) is an inherited disease that causes an increased risk of having chronic obstructive pulmonary disease (COPD), liver disease, skin problems …

In alpha-1 antitrypsin deficiency, the body’s normal production of the AAT protein is impaired, resulting in the destruction of sensitive lung tissue. Learn more about what causes this rare …

Aug 19, 2024 · AAT is made in the liver and it works to protect the lungs and liver. AAT deficiency means there is not enough of this protein in the body. It is caused by a genetic variant. The …

Dec 9, 2025 · Alpha-1 antitrypsin (AAT) is made by your liver and protects your lungs and liver from infections and inflammation. Your body may not be able to make enough healthy AAT if …

Alpha-1 antitrypsin levels in the blood depend on the genotype. Some mutant forms fail to fold properly and are, thus, targeted for destruction in the proteasome, whereas others have a …